Classification of preeclampsia according to molecular clusters with the goal of achieving personalized prevention
  • Metaadatok
Tartalom: https://publikacio.ppke.hu/id/eprint/3576/
Archívum: PPKE Publikáció Repozitórium
Gyűjtemény: Állapot = Megjelent
Szakterület = 03. Orvos- és egészségtudomány: 03.02. Klinikai orvostan: 03.02.02. Szülészet és nőgyógyászat
Szakterület = 03. Orvos- és egészségtudomány: 03.01. Általános orvostudomány: 03.01.04. Immunológia
Típus = Folyóiratcikk
Cím:
Classification of preeclampsia according to molecular clusters with the goal of achieving personalized prevention
Létrehozó:
Than Nándor Gábor
Romero Roberto
Posta Máté
Györffy Dániel
Szalai Gábor
Rossi Simona W
Szilágyi András
Hupuczi Petronella
Nagy Sándor
Török Olga
Tarca Adi L
Erez Offer
Ács Nándor
Papp Zoltán
Dátum:
2024
Téma:
03.01.04. Immunológia
03.02.02. Szülészet és nőgyógyászat
Tartalmi leírás:
The prevention of pre-eclampsia is difficult due to the syndromic nature and multiple underlying mechanisms of this severe complication of pregnancy. The current clinical distinction between early- and late-onset disease, although clinically useful, does not reflect the true nature and complexity of the pathologic processes leading to pre-eclampsia. The current gaps in knowledge on the heterogeneous molecular pathways of this syndrome and the lack of adequate, specific diagnostic methods are major obstacles to early screening and tailored preventive strategies. The development of novel diagnostic tools for detecting the activation of the identified disease pathways would enable early, accurate screening and personalized preventive therapies. We implemented a holistic approach that includes the utilization of different proteomic profiling methods of maternal plasma samples collected from various ethnic populations and the application of systems biology analysis to plasma proteomic, maternal demographic, clinical characteristic, and placental histopathologic data. This approach enabled the identification of four molecular subclasses of pre-eclampsia in which distinct and shared disease mechanisms are activated. The current review summarizes the results and conclusions from these studies and the research and clinical implications of our findings.
Nyelv:
angol
angol
Típus:
Folyóiratcikk
PeerReviewed
Formátum:
text
Azonosító:
Than Nándor Gábor; Romero Roberto; Posta Máté; Györffy Dániel; Szalai Gábor; Rossi Simona W; Szilágyi András; Hupuczi Petronella; Nagy Sándor; Török Olga; Tarca Adi L; Erez Offer; Ács Nándor; Papp Zoltán: Classification of preeclampsia according to molecular clusters with the goal of achieving personalized prevention. JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 161. ISSN 0165-0378 (2024)
MTMT:34477407 10.1016/j.jri.2023.104172
Kapcsolat:
MTMT:34477407 10.1016/j.jri.2023.104172