Type 1 cannabinoid receptor (CB1)-containing axons innervate hypophysiotropic thyrotropin-releasing hormone-synthesizing neurons
  • Metaadatok
Tartalom: https://publikacio.ppke.hu/id/eprint/3570/
Archívum: PPKE Publikáció Repozitórium
Gyűjtemény: Állapot = Megjelent
Szakterület = 03. Orvos- és egészségtudomány: 03.02. Klinikai orvostan: 03.02.18. Endokrinológia és anyagcserebetegségek (benne cukorbetegség, hormonok)
Szakterület = 03. Orvos- és egészségtudomány: 03.01. Általános orvostudomány: 03.01.02. Anatómia és morfológia
Típus = Folyóiratcikk
Cím:
Type 1 cannabinoid receptor (CB1)-containing axons innervate hypophysiotropic thyrotropin-releasing hormone-synthesizing neurons
Létrehozó:
Deli Levente
Wittmann Gábor
Kalló Imre
Lechan RM
Watanabe M
Liposits Zsolt
Fekete Csaba
Dátum:
2009
Téma:
03.01.02. Anatómia és morfológia
03.02.18. Endokrinológia és anyagcserebetegségek (benne cukorbetegség, hormonok)
Tartalmi leírás:
Hypophysiotropic thyrotropin-releasing hormone (TRH)-synthesizing neurons of the hypothalamic paraventricular nucleus (PVN) have a critical role in the regulation of the energy homeostasis through control of the hypothalamic-pituitary-thyroid axis. Recently, endocannabinoids have been shown to exert inhibitory effects on TRH neurons via the type 1 cannabinoid receptor (CB1). To understand the anatomical basis for this regulatory mechanism, we determined whether CB1 is contained in axons innervating hypophysiotropic TRH neurons using a recently developed antiserum against the C-terminal portion of mouse CB1. CB1-immunoreactive (IR) axons innervated densely the parvicellular subdivisions of the PVN where the hypophysiotropic TRH neurons are located. By double-labeling immunocytochemistry, CB1-IR varicosities were observed in juxtaposition to the vast majority of TRH neurons in the PVN. At the ultrastructural level, CB1-immunoreactivity was observed in the pre-terminal portion of axons establishing both symmetric and asymmetric synaptic specializations with the perikarya and dendrites of TRH neurons in the PVN. These data demonstrate that CB1 is abundantly present in axons that are in synaptic association with hypophysiotropic TRH neurons indicating an important role for endocannabinoids in the regulation of the hypothalamic-pituitary-thyroid axis. The presence of both symmetric and asymmetric type CB1 synapses on TRH neurons in the PVN suggests that endocannabinoids may influence both excitatory and inhibitory inputs of these neurons.
Nyelv:
angol
angol
Típus:
Folyóiratcikk
PeerReviewed
Formátum:
text
Azonosító:
Deli Levente; Wittmann Gábor; Kalló Imre; Lechan RM; Watanabe M; Liposits Zsolt; Fekete Csaba: Type 1 cannabinoid receptor (CB1)-containing axons innervate hypophysiotropic thyrotropin-releasing hormone-synthesizing neurons. ENDOCRINOLOGY, 150 (1). pp. 98-103. ISSN 0013-7227 (2009)
MTMT:109955 10.1210/en.2008-0330
Kapcsolat:
MTMT:109955 10.1210/en.2008-0330