ELM—the Eukaryotic Linear Motif resource—2024 update
  • Metaadatok
Tartalom: https://publikacio.ppke.hu/id/eprint/3486/
Archívum: PPKE Publikáció Repozitórium
Gyűjtemény: Állapot = Megjelent
Szakterület = 03. Orvos- és egészségtudomány: 03.01. Általános orvostudomány: 03.01.03. Humángenetika
Típus = Folyóiratcikk
Cím:
ELM—the Eukaryotic Linear Motif resource—2024 update
Létrehozó:
Kumar Manjeet
Michael Sushama
Alvarado-Valverde Jesús
Zeke András
Lazar Tamas
Glavina Juliana
Nagy-Kanta Eszter
Donagh Juan Mac
Kálmán Zsófia Etelka
Pascarelli Stefano
Palopoli Nicolas
Dobson László
Suarez Carmen Florencia
Van Roey Kim
Krystkowiak Izabella
Griffin Juan Esteban
Nagpal Anurag
Bhardwaj Rajesh
Diella Francesca
Mészáros Bálint
Dean Kellie
Davey Norman E
Pancsa Rita
Chemes Lucía B
Gibson Toby J
Dátum:
2024
Téma:
03.01.03. Humángenetika
Tartalmi leírás:
Short Linear Motifs (SLiMs) are the smallest structural and functional components of modular eukaryotic proteins. They are also the most abundant, especially when considering post-translational modifications. As well as being found throughout the cell as part of regulatory processes, SLiMs are extensively mimicked by intracellular pathogens. At the heart of the Eukaryotic Linear Motif (ELM) Resource is a representative (not comprehensive) database. The ELM entries are created by a growing community of skilled annotators and provide an introduction to linear motif functionality for biomedical researchers. The 2024 ELM update includes 346 novel motif instances in areas ranging from innate immunity to both protein and RNA degradation systems. In total, 39 classes of newly annotated motifs have been added, and another 17 existing entries have been updated in the database. The 2024 ELM release now includes 356 motif classes incorporating 4283 individual motif instances manually curated from 4274 scientific publications and including >700 links to experimentally determined 3D structures. In a recent development, the InterPro protein module resource now also includes ELM data. ELM is available at: http://elm.eu.org.
Nyelv:
angol
angol
Típus:
Folyóiratcikk
PeerReviewed
Formátum:
text
Azonosító:
Kumar Manjeet; Michael Sushama; Alvarado-Valverde Jesús; Zeke András; Lazar Tamas; Glavina Juliana; Nagy-Kanta Eszter; Donagh Juan Mac; Kálmán Zsófia Etelka; Pascarelli Stefano; Palopoli Nicolas; Dobson László; Suarez Carmen Florencia; Van Roey Kim; Krystkowiak Izabella; Griffin Juan Esteban; Nagpal Anurag; Bhardwaj Rajesh; Diella Francesca; Mészáros Bálint; Dean Kellie; Davey Norman E; Pancsa Rita; Chemes Lucía B; Gibson Toby J: ELM—the Eukaryotic Linear Motif resource—2024 update. NUCLEIC ACIDS RESEARCH, 52 (D1). D442-D455. ISSN 0305-1048 (2024)
MTMT:34391702 10.1093/nar/gkad1058
Kapcsolat:
MTMT:34391702 10.1093/nar/gkad1058