A Comprehensive Overview on Chemotherapy-Induced Cardiotoxicity: Insights into the Underlying Inflammatory and Oxidative Mechanisms
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Tartalom: https://real.mtak.hu/225077/
Archívum: REAL
Gyűjtemény: Status = Published
Subject = R Medicine / orvostudomány: RC Internal medicine / belgyógyászat: RC0254 Neoplasms. Tumors. Oncology (including Cancer) / daganatok, tumorok, onkológia
Type = Article
Subject = R Medicine / orvostudomány: RC Internal medicine / belgyógyászat: RC685 Diseases of the heart, Cardiology / kardiológia
Cím:
A Comprehensive Overview on Chemotherapy-Induced Cardiotoxicity: Insights into the Underlying Inflammatory and Oxidative Mechanisms
Létrehozó:
Nagy, András Levente
Börzsei, Denise
Nagyné Hoffmann, Alexandra
Török, Szilvia
Veszelka, Médea
Almási, Nikoletta
Varga, Csaba
Szabó, Renáta
Dátum:
2024
Téma:
RC0254 Neoplasms. Tumors. Oncology (including Cancer) / daganatok, tumorok, onkológia
RC685 Diseases of the heart, Cardiology / kardiológia
Tartalmi leírás:
While oncotherapy has made rapid progress in recent years, side effects of anti-cancer drugs and treatments have also come to the fore. These side effects include cardiotoxicity, which can cause irreversible cardiac damages with long-term morbidity and mortality. Despite the continuous in-depth research on anti-cancer drugs, an improved knowledge of the underlying mechanisms of cardiotoxicity are necessary for early detection and management of cardiac risk. Although most reviews focus on the cardiotoxic effect of a specific individual chemotherapeutic agent, the aim of our review is to provide comprehensive insight into various agents that induced cardiotoxicity and their underlying mechanisms. Characterization of these mechanisms are underpinned by research on animal models and clinical studies. In order to gain insight into these complex mechanisms, we emphasize the role of inflammatory processes and oxidative stress on chemotherapy-induced cardiac changes. A better understanding and identification of the interplay between chemotherapy and inflammatory/oxidative processes hold some promise to prevent or at least mitigate cardiotoxicity-associated morbidity and mortality among cancer survivors.
Nyelv:
angol
Típus:
Article
PeerReviewed
info:eu-repo/semantics/article
Formátum:
text
Azonosító:
Nagy, András Levente and Börzsei, Denise and Nagyné Hoffmann, Alexandra and Török, Szilvia and Veszelka, Médea and Almási, Nikoletta and Varga, Csaba and Szabó, Renáta (2024) A Comprehensive Overview on Chemotherapy-Induced Cardiotoxicity: Insights into the Underlying Inflammatory and Oxidative Mechanisms. CARDIOVASCULAR DRUGS AND THERAPY. ISSN 0920-3206
Kapcsolat:
MTMT:34947620 10.1007/s10557-024-07574-0
Létrehozó:
cc_by