1-Pyrene Carboxylic Acid: An Internalization Enhancer for Short Oligoarginines
  • Metaadatok
Tartalom: https://real.mtak.hu/224269/
Archívum: REAL
Gyűjtemény: Status = Published
Subject = Q Science / természettudomány: QD Chemistry / kémia
Type = Article
Cím:
1-Pyrene Carboxylic Acid: An Internalization Enhancer for Short Oligoarginines
Létrehozó:
Bató, Csaba
Szabó, Ildikó
Yousef, Mo’ath
Lenzinger, Dorina
Grébecz, Fülöp Károly
Visnovitz, Tamás
Bősze, Szilvia
Bánóczi, Zoltán
Mező, Gábor
Dátum:
2025
Téma:
QD Chemistry / kémia
Tartalmi leírás:
Getting through the cell membrane is challenging, and transporting a therapeutic agent while entering the cell is even more complicated. Cell-penetrating peptides (CPPs) are valuable tools for solving this problem, although they have drawbacks. In this work, the synthesis and investigation of efficient CPPs are described. We used an aromatic group, 1-pyrene carboxylic acid (PCA), to enhance internalization. We designed oligoarginines to investigate the effect of PCA in different positions at the N-terminus or in the side chain. Our novel peptide derivatives showed remarkable internalization on tumor cell lines, and more than one endocytic pathway plays a role in their internalization mechanism. With this modification, there is an opportunity to design short oligoarginines that can rival well-known CPPs like octaarginine in internalization.
Nyelv:
angol
Típus:
Article
PeerReviewed
info:eu-repo/semantics/article
Formátum:
text
Azonosító:
Bató, Csaba and Szabó, Ildikó and Yousef, Mo’ath and Lenzinger, Dorina and Grébecz, Fülöp Károly and Visnovitz, Tamás and Bősze, Szilvia and Bánóczi, Zoltán and Mező, Gábor (2025) 1-Pyrene Carboxylic Acid: An Internalization Enhancer for Short Oligoarginines. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 26 (5). No. 2202. ISSN 1661-6596
Kapcsolat:
MTMT:35801901 10.3390/ijms26052202
Létrehozó:
cc_by