Talampanel improves the functional deficit after transient focal cerebral ischemia in rats. A 30-day follow up study.
  • Metaadatok
Tartalom: https://publikacio.ppke.hu/id/eprint/2379/
Archívum: PPKE Publikáció Repozitórium
Gyűjtemény: Állapot = Megjelent
Szakterület = 03. Orvos- és egészségtudomány: 03.01. Általános orvostudomány: 03.01.05. Idegtudományok (benne pszichofiziológia)
Típus = Folyóiratcikk
Cím:
Talampanel improves the functional deficit after transient focal cerebral ischemia in rats. A 30-day follow up study.
Létrehozó:
Erdő Franciska
Berzsenyi P
Nemet L
Andrasi F
Dátum:
2006
Téma:
03.01.05. Idegtudományok (benne pszichofiziológia)
Tartalmi leírás:
The neuroprotective effect of talampanel, a negative allosteric modulator of alpha-amino-3-hydroxy-methyl-4-isoxazolyl-propionic acid (AMPA) receptors has been described previously. However, in these studies the histological changes and not the functional consequences of the brain damage were evaluated. The aim of present investigation was to analyze the sensorimotor function after stroke and to test the influence of talampanel (GYKI-53773, LY-300164) by 30-day monitoring in rats. After 1h middle cerebral artery occlusion (MCAO) general 'well-being', neurological status, spontaneous motor activity, rotation, motor coordination, balancing, muscle strength and reaction time were followed for 1 month. Talampanel (6 x 10 mg/kg i.p. given on the day of stroke) improved the motor coordination in rotarod (p < 0.01) and beam walking (p < 0.01) tests, reduced the number of stroke-induced rotations (p < 0.05), shortened the reflex time on the forelimb contralateral to brain ischemia and improved the survival rate comparing with vehicle treated control. After stroke, serious sensorimotor deficits appeared in rats but they showed partial spontaneous recovery after 30 days. Talampanel treatment enhanced the rate of functional improvement without changing the morphology at the end of the experiment. Our results indicate that modulation of AMPA receptors by talampanel can be a promising therapeutic approach to the treatment of stroke.
Nyelv:
angol
angol
Típus:
Folyóiratcikk
PeerReviewed
Formátum:
text
Azonosító:
Erdő Franciska; Berzsenyi P; Nemet L; Andrasi F: Talampanel improves the functional deficit after transient focal cerebral ischemia in rats. A 30-day follow up study. BRAIN RESEARCH BULLETIN, 68 (4). pp. 269-276. ISSN 0361-9230 (2006)
MTMT:2802857 10.1016/j.brainresbull.2005.08.018
Kapcsolat:
MTMT:2802857 10.1016/j.brainresbull.2005.08.018