The AMPA-antagonist talampanel is neuroprotective in rodent models of focal cerebral ischemia.
  • Metaadatok
Tartalom: https://publikacio.ppke.hu/id/eprint/2378/
Archívum: PPKE Publikáció Repozitórium
Gyűjtemény: Állapot = Megjelent
Szakterület = 03. Orvos- és egészségtudomány: 03.01. Általános orvostudomány: 03.01.05. Idegtudományok (benne pszichofiziológia)
Típus = Folyóiratcikk
Cím:
The AMPA-antagonist talampanel is neuroprotective in rodent models of focal cerebral ischemia.
Létrehozó:
Erdő Franciska
Berzsenyi P
Andrasi F
Dátum:
2005
Téma:
03.01.05. Idegtudományok (benne pszichofiziológia)
Tartalmi leírás:
Cerebroprotection after administration of glutamate receptor antagonists has been well documented. The present study is intended to determine whether the non-competitive alpha-amino-3-hydroxy-methyl-4-isoxazolyl-propionic acid (AMPA) receptor antagonist talampanel, known as antiepileptic drug, has neuroprotective effects in stroke models in rodents. The infarct size was measured in three models of stroke by 2,3,5-triphenyltetrazolium chloride staining. Therapeutic time window was also examined in rats subjected to 1h middle cerebral artery occlusion. The degree of neuroprotection was tested in mice, using 1.5, 2 h or permanent middle cerebral artery occlusions. Effect on photochemically induced thrombosis was investigated in rats applying 30 min time window after brain irradiation. Talampanel reduced the infarct size by 47.3% (p<0.01) after a 30 min delay and 48.5% (p<0.01) after 2 h delay following middle cerebral artery occlusion in rats. In mice, talampanel reduced the extension of the infarcted tissue at the levels of striatum and hippocampus by 44.5% (p<0.05) and 39.3% (p<0.01) after 1.5 h transient ischemia and still caused 37.0% (p<0.05) and 37.0% (p<0.05) inhibitions when 2 h occlusion was applied. In photothrombosis talampanel showed a 40.1% (p<0.05) inhibition. Protective actions of talampanel in various stroke models, in rats and mice, suggest a possible therapeutic role of the compound in stroke patients.
Nyelv:
angol
angol
Típus:
Folyóiratcikk
PeerReviewed
Formátum:
text
Azonosító:
Erdő Franciska; Berzsenyi P; Andrasi F: The AMPA-antagonist talampanel is neuroprotective in rodent models of focal cerebral ischemia. BRAIN RESEARCH BULLETIN, 66 (1). pp. 43-49. ISSN 0361-9230 (2005)
MTMT:2802858 10.1016/j.brainresbull.2005.03.012
Kapcsolat:
MTMT:2802858 10.1016/j.brainresbull.2005.03.012