Charged sequence motifs increase the propensity towards liquid–liquid phase separation
  • Metaadatok
Tartalom: https://publikacio.ppke.hu/id/eprint/1622/
Archívum: PPKE Publikáció Repozitórium
Gyűjtemény: Állapot = Megjelent
Szakterület = 01. Természettudományok: 01.06. Biológiai tudományok: 01.06.03. Biokémia és molekuláris biológia
Típus = Folyóiratcikk
Cím:
Charged sequence motifs increase the propensity towards liquid–liquid phase separation
Létrehozó:
Szabó András László
Sánta Anna
Pancsa Rita
Gáspári Zoltán
Dátum:
2022
Téma:
01.06.03. Biokémia és molekuláris biológia
Tartalmi leírás:
Protein phase separation is a major governing factor in multiple cellular processes, such as RNA metabolism and those involving RNA-binding proteins. Despite many key observations, the exact structural characteristics of proteins involved in the phase separation process are still not fully deciphered. In this work, we show that proteins harbouring sequence regions with specific charged residue patterns are significantly associated with liquid–liquid phase separation. In particular, regions with repetitive arrays of alternating charges show the strongest association, whereas segments with generally high charge density and single α-helices also show detectable but weaker connections. © 2022 The Authors. FEBS Letters published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.
Nyelv:
angol
angol
Típus:
Folyóiratcikk
PeerReviewed
Formátum:
text
Azonosító:
Szabó András László; Sánta Anna; Pancsa Rita; Gáspári Zoltán: Charged sequence motifs increase the propensity towards liquid–liquid phase separation. FEBS LETTERS, 596 (8). pp. 1013-1028. ISSN 0014-5793 (2022)
MTMT:32678645 10.1002/1873-3468.14294
Kapcsolat:
MTMT:32678645 10.1002/1873-3468.14294