Resonance assignment of the Shank1 PDZ domain
  • Metaadatok
Tartalom: https://publikacio.ppke.hu/id/eprint/1621/
Archívum: PPKE Publikáció Repozitórium
Gyűjtemény: Állapot = Megjelent
Szakterület = 01. Természettudományok: 01.06. Biológiai tudományok: 01.06.03. Biokémia és molekuláris biológia
Típus = Folyóiratcikk
Cím:
Resonance assignment of the Shank1 PDZ domain
Létrehozó:
Sánta Anna
Czajlik András
Batta Gyula
Péterfia Bálint
Gáspári Zoltán
Dátum:
2022
Téma:
01.06.03. Biokémia és molekuláris biológia
Tartalmi leírás:
Shank proteins are among the most abundant and well-studied postsynaptic scaffold proteins. Their PDZ domain has unique characteristics as one of its loop regions flanking the ligand-binding site is uniquely long and has also been implicated in the formation of PDZ dimers. Here we report the initial characterization of the Shank1 PDZ domain by solution NMR spectroscopy. The assigned chemical shifts are largely consistent with the common features of PDZ domains in general and the available Shank PDZ crystal structures in particular. Our analysis suggests that under the conditions investigated, the domain is monomeric and the unique loop harbors a short helical segment, observed in only one of the known X-ray structures so far. Our work stresses the importance of solution-state investigations to fully decipher the functional relevance of the structural and dynamical features unique to Shank PDZ domains.
Nyelv:
angol
angol
Típus:
Folyóiratcikk
PeerReviewed
Formátum:
text
Azonosító:
Sánta Anna; Czajlik András; Batta Gyula; Péterfia Bálint; Gáspári Zoltán: Resonance assignment of the Shank1 PDZ domain. BIOMOLECULAR NMR ASSIGNMENTS, 16 (1). pp. 121-127. ISSN 1874-2718 (2022)
MTMT:32625251 10.1007/s12104-022-10069-4
Kapcsolat:
MTMT:32625251 10.1007/s12104-022-10069-4