Initial and ongoing tobacco smoking elicits vascular damage and distinct inflammatory response linked to neurodegeneration

Garza, Alejandra P.

Morton, Lorena

Pállinger, Éva

Buzás, Edit I.

Schreiber, Stefanie

Schott, Björn H.

Dunay, Ildikó Rita

2023

QH426 Genetics / genetika, örökléstan

R1 Medicine (General) / orvostudomány általában

RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry / idegkórtan, neurológia, pszichiátria

RC554 Personality disorders. Behavior problems / személyiségzavarok, viselkedési problémák

Tobacco smoking is strongly linked to vascular damage contributing to the development of hypertension, atherosclerosis, as well as increasing the risk for neurodegeneration. Still, the involvement of the innate immune system in the development of vascular damage upon chronic tobacco use before the onset of clinical symptoms is not fully characterized. Our data provide evidence that a single acute exposure to tobacco elicits the secretion of extracellular vesicles expressing CD105 and CD49e from endothelial cells, granting further recognition of early preclinical biomarkers of vascular damage. Furthermore, we investigated the effects of smoking on the immune system of healthy asymptomatic chronic smokers compared to never-smokers, focusing on the innate immune system. Our data reveal a distinct immune landscape representative for early stages of vascular damage in clinically asymptomatic chronic smokers, before tobacco smoking related diseases develop. These results indicate a dysregulated immuno-vascular axis in chronic tobacco smokers that are otherwise considered as healthy individuals. The distinct alterations are characterized by increased CD36 expression by the blood monocyte subsets, neutrophilia and increased plasma IL-18 and reduced levels of IL-33, IL-10 and IL-8. Additionally, reduced levels of circulating BDNF and elevated sTREM2, which are associated with neurodegeneration, suggest a considerable impact of tobacco smoking on CNS function in clinically healthy individuals. These findings provide profound insight into the initial and ongoing effects of tobacco smoking and the potential vascular damage contributing to neurodegenerative disorders, specifically cerebrovascular dysfunction and dementia. © 2023 The Authors

angol

Article

PeerReviewed

info:eu-repo/semantics/article

text

https://real.mtak.hu/191689/1/1-s2.0-S266635462300011X-main.pdf

Garza, Alejandra P. and Morton, Lorena and Pállinger, Éva and Buzás, Edit I. and Schreiber, Stefanie and Schott, Björn H. and Dunay, Ildikó Rita (2023) Initial and ongoing tobacco smoking elicits vascular damage and distinct inflammatory response linked to neurodegeneration. BRAIN BEHAVIOR IMMUNITY - HEALTH, 28. No.-100597. ISSN 2666-3546

https://real.mtak.hu/191689/

https://doi.org/10.1016/j.bbih.2023.100597

MTMT:33719224 10.1016/j.bbih.2023.100597

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