“The Effects of Silver Nanoparticle Shape on Protein Adsorption and Neural Stem Cell Viability”
  • Metaadatok
Tartalom: http://real.mtak.hu/160666/
Archívum: REAL
Gyűjtemény: Status = Published
Subject = R Medicine / orvostudomány: R1 Medicine (General) / orvostudomány általában
Type = Article
Subject = R Medicine / orvostudomány: R1 Medicine (General) / orvostudomány általában: R850-854 Experimental medicine / kisérleti orvostudomány
Cím:
“The Effects of Silver Nanoparticle Shape on Protein Adsorption and Neural Stem Cell Viability”
Létrehozó:
Kumarasamy, Murali
Tran, Ngoc
Patarroyo, Javier
Mishra, Sushmita
Monopoli, Marco
Madarász, Emilia
Dátum:
2022
Téma:
R1 Medicine (General) / orvostudomány általában
R850-854 Experimental medicine / kisérleti orvostudomány
Tartalmi leírás:
Silver nanoparticles (AgNPs) are important and widely used as antimicrobials and nanodrug carriers. The increased use of AgNPs in consumer products has raised concerns about nanosafety; for instance, AgNPs may be inhaled and translocated to the brain via olfactory neural stem cells/progenitors. While the biological effects of nanoparticle size have been widely investigated, there are little data on the effects of particle shape on cellular phenotype. Therefore, here we investigated the interactions between AgNP spheres, rods, cubes, and triangles and human plasma proteins as well as their effects on the viability of NE-4C neural stem cells. Nanoparticles were synthesized by wet chemistry methods and characterized by UV-vis spectroscopy, dynamic light scattering, zeta potential measurement, transmission electron microscopy, nanoparticle tracking analysis, and differential centrifugal sedimentation. NE-4C cell viability was assessed using the MTT reduction assay, and the cellular uptake of differently shaped nanoparticles was monitored by electron microscopy. All 50 nm (in at least one dimension) AgNPs exerted toxic effects, with rods and cubes displaying greater toxicity than spheres and triangles. These cellular and physicochemical results indicate that edges on the AgNPs increase toxicity, presumably due to enhanced ion dissolution from the edges.
Nyelv:
angol
Típus:
Article
PeerReviewed
info:eu-repo/semantics/article
Formátum:
text
Azonosító:
Kumarasamy, Murali and Tran, Ngoc and Patarroyo, Javier and Mishra, Sushmita and Monopoli, Marco and Madarász, Emilia (2022) “The Effects of Silver Nanoparticle Shape on Protein Adsorption and Neural Stem Cell Viability”. CHEMISTRYSELECT, 7 (39). ISSN 2365-6549
Kapcsolat:
MTMT:33210595 10.1002/slct.202201917