| Tartalom: |
http://real.mtak.hu/119873/ |
| Archívum: |
REAL |
| Gyűjtemény: |
Status = Published
Subject = Q Science / természettudomány: QK Botany / növénytan: QK40 Plant histology / nővényszövettan
Type = Article
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| Cím: |
Expression of the translation termination factor eRF1 is autoregulated by translational readthrough and 3'UTR intron-mediated NMD in Neurospora crassa
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| Létrehozó: |
Kurilla, Anita
Szőke, Anita
Auber, Andor
Káldi, Krisztina
Silhavy, Dániel
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| Kiadó: |
John Wiley & Sons Ltd.
|
| Dátum: |
2020
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| Téma: |
QK40 Plant histology / nővényszövettan
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| Tartalmi leírás: |
Eukaryotic release factor 1 (eRF1) is a translation termination factor that binds to the ribosome at stop codons. The expression of eRF1 is strictly controlled, since its concentration defines termination efficiency and frequency of translational readthrough. Here, we show that eRF1 expression in Neurospora crassa is controlled by an autoregulatory circuit that depends on the specific 3'UTR structure of erf1 mRNA. The stop codon context of erf1 promotes readthrough that protects the mRNA from its 3'UTR-induced nonsense-mediated mRNA decay (NMD). High eRF1 concentration leads to inefficient readthrough, thereby allowing NMD-mediated erf1 degradation. We propose that eRF1 expression is controlled by similar autoregulatory circuits in many fungi and seed plants and discuss the evolution of autoregulatory systems of different translation termination factors.
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| Nyelv: |
angol
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| Típus: |
Article
PeerReviewed
info:eu-repo/semantics/article
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| Formátum: |
text
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| Azonosító: |
Kurilla, Anita and Szőke, Anita and Auber, Andor and Káldi, Krisztina and Silhavy, Dániel (2020) Expression of the translation termination factor eRF1 is autoregulated by translational readthrough and 3'UTR intron-mediated NMD in Neurospora crassa. FEBS LETTERS, 594 (21). pp. 3504-3517. ISSN 0014-5793 (print); 1873-3468 (online)
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| Kapcsolat: |
MTMT:31612927 10.1002/1873-3468.13918
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| Létrehozó: |
cc_by_nc_nd
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