5'-nucleotidases, nucleosides and their distribution in the brain: pathological and therapeutic implications
  • Metaadatok
Tartalom: http://real.mtak.hu/17107/
Archívum: REAL
Gyűjtemény: Status = Published
Subject = R Medicine / orvostudomány: RZ Other systems of medicine / orvostudomány egyéb területei
Type = Article
Cím:
5'-nucleotidases, nucleosides and their distribution in the brain: pathological and therapeutic implications
Létrehozó:
Kovács, Zsolt
Dobolyi, Árpád
Kékesi, Katalin A.
Juhász, Gábor
Kiadó:
Bentham Science Publishers
Dátum:
2013
Téma:
RZ Other systems of medicine / orvostudomány egyéb területei
Tartalmi leírás:
Elements of the nucleoside system (nucleoside levels, 5'-nucleotidases (5'NTs) and other nucleoside metabolic enzymes, nucleoside transporters and nucleoside receptors) are unevenly distributed in the brain, suggesting that nucleosides have region-specific functions in the human brain. Indeed, adenosine (Ado) and non-Ado nucleosides, such as guanosine (Guo), inosine (Ino) and uridine (Urd), modulate both physiological and pathophysiological processes in the brain, such as sleep, pain, memory, depression, schizophrenia, epilepsy, Huntington's disease, Alzheimer's disease and Parkinson's disease. Interactions have been demonstrated in the nucleoside system between nucleoside levels and the activities of nucleoside metabolic enzymes, nucleoside transporters and Ado receptors in the human brain. Alterations in the nucleoside system may induce pathological changes, resulting in central nervous system (CNS) diseases. Moreover, several CNS diseases such as epilepsy may be treated by modulation of the nucleoside system, which is best achieved by modulating 5'NTs, as 'NTs exhibit numerous functions in the CNS, including intracellular and extracellular formation of nucleosides, termination of nucleoside triphosphate signaling, cell adhesion, synaptogenesis and cell proliferation. Thus, modulation of 5'NT activity may be a promising new therapeutic tool for treating several CNS diseases. The present article describes the regionally different activities of the nucleoside system, demonstrates the associations between these activities and 5'NT activity and discusses the therapeutic implications of these associations.
Nyelv:
angol
Típus:
Article
PeerReviewed
info:eu-repo/semantics/article
Formátum:
text
Azonosító:
Kovács, Zsolt and Dobolyi, Árpád and Kékesi, Katalin A. and Juhász, Gábor (2013) 5'-nucleotidases, nucleosides and their distribution in the brain: pathological and therapeutic implications. Current medicinal chemistry, 20 (34). pp. 4217-4240. ISSN 1875-533X
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