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A comparative study on anti-inflammatory drug combinations in domestic pigeons with experimentally induced acute arthritis

  • Metaadatok
Tartalom: http://real.mtak.hu/106351/
Archívum: REAL
Gyűjtemény: Status = Published
Subject = S Agriculture / mezőgazdaság: SV Veterinary science / állatorvostudomány
Type = Article
Cím:
A comparative study on anti-inflammatory drug combinations in domestic pigeons with experimentally induced acute arthritis
Létrehozó:
Salandari, Sajedeh
Shomali, Tahoora
Mosleh, Najmeh
Nazifi, Saeed
Kiadó:
Akadémiai Kiadó
Dátum:
2019
Téma:
SV Veterinary science / állatorvostudomány
Tartalmi leírás:
The study compares the effect of one-time administration of nonsteroidal and/or steroidal anti-inflammatory combinations by topical or intramuscular (IM) routes to pigeons with monosodium urate (MSU)-induced arthritis. Forty-five adult domestic pigeons were assigned into nine equal groups: NC, negative control; PC, positive control with arthritis; sham, sham control; T1, meloxicam + hydrocortisone; T2, dexamethasone + piroxicam; T3, meloxicam + dexamethasone; T4, hydrocortisone + piroxicam; T5, dexamethasone + hydrocortisone; T6, meloxicam + piroxicam. Arthritis was also induced in T1 to T6 birds. Meloxicam and dexamethasone were administered by IM injection and the other drugs topically right after the induction of arthritis. Different drug combinations significantly decreased one-leg standing time. Induction of arthritis significantly increased TNF-α and IL-6 levels in synovial fluid and serum corticosterone and epinephrine in the PC group. Administration of drugs to birds of Groups T1 and T5 did not significantly change corticosterone concentration, while all different drug combinations decreased epinephrine level. Drug combinations that demonstrated better analgesic effect more strongly reduced serum epinephrine concentration. Meloxicam + hydrocortisone was the most effective combination in reducing inflammatory cytokines. In conclusion, one-time combination therapy with anti-inflammatory agents was effective in the acute management of inflammatory pain due to MSU-induced arthritis in pigeons, even by the topical route.
Nyelv:
magyar
Típus:
Article
PeerReviewed
info:eu-repo/semantics/article
Formátum:
text
Azonosító:
Salandari, Sajedeh and Shomali, Tahoora and Mosleh, Najmeh and Nazifi, Saeed (2019) A comparative study on anti-inflammatory drug combinations in domestic pigeons with experimentally induced acute arthritis. Acta Veterinaria Hungarica, 67 (4). pp. 588-601. ISSN 0236-6290
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