A Coordination Chemistry Approach to Fine‐Tune the Physicochemical Parameters of Lanthanide Complexes Relevant to Medical Applications
  • Metaadatok
Tartalom: http://real.mtak.hu/84066/
Archívum: REAL
Gyűjtemény: Status = Published
Subject = Q Science / természettudomány: QD Chemistry / kémia: QD01 Analytical chemistry / analitikai kémia
Type = Article
Cím:
A Coordination Chemistry Approach to Fine‐Tune the Physicochemical Parameters of Lanthanide Complexes Relevant to Medical Applications
Létrehozó:
Le Fur, Mariane
Tóth-Molnár, Enikő
Kálmán, Ferenc K.
Fougére, Olivier
Esteban-Gómez, David
Rousseaux, Olivier
Tripier, Raphaël
Tircsó, Gyula
Platas-Iglesias, Carlos
Kiadó:
Wiley
Dátum:
2018
Téma:
QD01 Analytical chemistry / analitikai kémia
Tartalmi leírás:
The geometric features of two pyclen‐based ligands possessing identical donor atoms but different site organization have a profound impact in their complexation properties toward lanthanide ions. The ligand containing two acetate groups and a picolinate arm arranged in a symmetrical fashion (L1) forms a Gd3+ complex being two orders of magnitude less stable than its dissymmetric analogue GdL2. Besides, GdL1 experiences a much faster dissociation following the acid‐catalyzed mechanism than GdL2. On the contrary, GdL1 exhibits a lower exchange rate of the coordinated water molecule compared to GdL2. These very different properties are related to different strengths of the Gd‐ligand bonds associated to steric effects, which hinder the coordination of a water molecule in GdL2 and the binding of acetate groups in GdL1.
Nyelv:
magyar
Típus:
Article
PeerReviewed
info:eu-repo/semantics/article
Formátum:
text
Azonosító:
Le Fur, Mariane and Tóth-Molnár, Enikő and Kálmán, Ferenc K. and Fougére, Olivier and Esteban-Gómez, David and Rousseaux, Olivier and Tripier, Raphaël and Tircsó, Gyula and Platas-Iglesias, Carlos (2018) A Coordination Chemistry Approach to Fine‐Tune the Physicochemical Parameters of Lanthanide Complexes Relevant to Medical Applications. Chemistry - A European Journal, 24. pp. 3127-3131. ISSN 1521-3765
Kapcsolat:
10.1002/chem.201705528