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Excessive aggression as model of violence : a critical evaluation of current preclinical methods |
Tartalom: | http://real.mtak.hu/8819/ |
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Archívum: | REAL |
Gyűjtemény: |
Status = Published
Subject = B Philosophy. Psychology. Religion / filozófia, pszichológia, vallás: BF Psychology / lélektan: BF20 Abnormal psychology / lelki betegségek Subject = R Medicine / orvostudomány: R1 Medicine (General) / orvostudomány általában Subject = B Philosophy. Psychology. Religion / filozófia, pszichológia, vallás: BF Psychology / lélektan: BF07 Individual psychology / individuálpszichológia Type = Article |
Cím: |
Excessive aggression as model of violence : a critical
evaluation of current preclinical methods
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Létrehozó: |
Miczek, Klaus A.
Boer, Sietse F. de
Haller, József
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Dátum: |
2013
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Téma: |
BF07 Individual psychology / individuálpszichológia
BF20 Abnormal psychology / lelki betegségek
R1 Medicine (General) / orvostudomány általában
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Tartalmi leírás: |
Rationale
Preclinical experimental models of pathological
aggressive behavior are a sorely understudied and difficult
research area.
Objectives
How valid, reliable, productive, and informative
are the most frequently used animal models of excessive
aggressive behavior?
Methods
The rationale, key methodological features, sup-
porting data, and arguments as well as their disadvantages
and limitations of the most frequently used animal models
for excessive aggressive behavior are summarized and their
validity and reliability are evaluated.
Results
Excessive aggressive behavior is validly and reliably
seen in (1) a proportion of feral-derived rats and selectively
bred mice; (2) rats with compromised adrenal function resulting in a hypoglucocorticoid state; (3) a significant mi-
nority of mice, rats, and monkeys after consumption of a
moderate dose of alcohol; and (4) resident animals of various
species after social instigation. Limitations of these proce-
dures include restrictive animal research regulations, the re-
quirement of expertise in surgical, pharmacological, and
behavioral techniques, and the behaviorally impoverished
mouse strains that are used in molecular genetics research.
Promising recent initiatives for novel experimental models
include aggressive behaviors that are evoked by optogenetic
stimulation and induced by the manipulation of early social
experiences such as isolation rearing or social stress.
Conclusions
One of the most significant challenges for
animal models of excessive, potentially abnormal aggres-
sive behavior is the characterization of distinctive neurobi-
ological mechanisms that di
ffer from those governing
species-typical aggressive behavior. Identifying novel targets
for effective intervention requires increased understanding of
the distinctive molecular, cellular, and circuit mechanisms for
each type of abnormal aggressive behavior.
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Típus: |
Article
PeerReviewed
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Formátum: |
text
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Azonosító: |
Miczek, Klaus A. and Boer, Sietse F. de and Haller, József (2013) Excessive aggression as model of violence : a critical evaluation of current preclinical methods. PSYCHOPHARMACOLOGY, 226 (3). pp. 445-458. ISSN 0033-3158
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