20-Hydroxyecdysone increases fiber size in a muscle-specific fashion in rat
  • Metaadatok
Tartalom: http://www.sciencedirect.com/science/article/pii/S0944711308000901
Archívum: REAL
Gyűjtemény: Status = Published
Subject = R Medicine / orvostudomány: R1 Medicine (General) / orvostudomány általában
Subject = R Medicine / orvostudomány: RM Therapeutics. Pharmacology / terápia, gyógyszertan
Type = Article
Cím:
20-Hydroxyecdysone increases fiber size in a muscle-specific fashion in rat
Létrehozó:
Tóth, Noémi
Szabó, András
Kacsala, Péter
Héger, Júlia
Zádor, Ernő
Dátum:
2008
Téma:
R1 Medicine (General) / orvostudomány általában
RM Therapeutics. Pharmacology / terápia, gyógyszertan
Tartalmi leírás:
20-Hydroxyecdysone (20E) is an ecdysteroid hormone that regulates moulting in insects. Interestingly, 20E is also found most abundantly in plant species and has anabolic effects in vertebrates, i.e. increasing muscle size without androgen influence. The effect of 20E on slow and fast fiber types of skeletal muscle has not been reported yet. Here we present that 20E affects the size (cross-sectional area, CSA) of the different fiber types in a muscle-specific manner. The effect on fiber size was modified by the distance from the site of the treatment and the presence of a regenerating soleus muscle in the animal. Besides the fiber size, 20E also increased the myonuclear number in the fibers of normal and regenerating muscles, suggesting the activation of satellite cells. According to our results 20E may provide an alternative for substitution of anabolic–androgenic steroids in therapeutic treatments against muscle atrophy.
Típus:
Article
PeerReviewed
Formátum:
text
Azonosító:
Tóth, Noémi and Szabó, András and Kacsala, Péter and Héger, Júlia and Zádor, Ernő (2008) 20-Hydroxyecdysone increases fiber size in a muscle-specific fashion in rat. PHYTOMEDICINE, 15 (9). pp. 691-698. ISSN 0944-7113
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