The Effects of Echinacea (EP107TM) on Anxiety: A Comparison of Anxiety Measures in a Randomized, Double Blind, Placebo-Controlled Study
  • Metaadatok
Tartalom: http://hdl.handle.net/20.500.12944/102229
Archívum: Közszolgálati Tudásportál
Gyűjtemény: Publikációk
Nemeskürty István Tanárképző Kar
Cím:
The Effects of Echinacea (EP107TM) on Anxiety: A Comparison of Anxiety Measures in a Randomized, Double Blind, Placebo-Controlled Study
Létrehozó:
Haller, József
Faludi, Gábor
Kovacs, Gábor
Purebl, György
Füzesi, Zoltán
F. Freund, Tamás
Téma:
echinacea
anxiety
humans
psychic anxiety
physical anxiety
herbal anxiolytic
Orvostudományok
Orvostudományok/Klinikai orvostudományok
Tartalmi leírás:
Background/Objectives: Echinacea extracts with unique alkamide profiles (EP107™) have been shown to affect upper respiratory tract infections and reduce anxiety in both animals and humans. However, a recent study found that a similar extract did not reduce anxiety more than a placebo, although it did enhance well-being and produced antidepressant-like effects. We hypothesized that the discrepancy arose from the differences in the anxiety assessment methods used. The study that observed no effects used the Clinically Useful Anxiety Outcome Scale, which focuses on physical symptoms, while earlier studies used the State-Trait Anxiety Inventory, which focuses on psychic symptoms. Methods: To investigate the influence of the anxiety measure on the detectability of anxiolytic effects, we examined the effects of Echinacea EP107TM using the Hospital Anxiety and Depression Scale–anxiety subscale (HADS-A), which focuses on psychic symptoms, and the Hamilton Anxiety Rating Scale (HAM-A), most items of which involve physical symptoms. The study was placebo-controlled, double-blind, and multicenter. Results: The extract significantly alleviated anxiety compared to placebo when measured with HADS-A. HAM-A total scores did not show significant treatment effects. However, Echinacea was superior to placebo in three psychic anxiety items on the HAM-A. Conclusions: These findings suggest that Echinacea EP107TM reduces psychic anxiety without affecting somatic symptoms. This indicates that the extract may be useful in mild or early-phase anxiety when somatic symptoms are not prominent.
Típus:
info:eu-repo/semantics/other
Formátum:
application/pdf
Azonosító:
nke:1424-8247
nke:10.3390/ph18020264
nke:35764352
nke:10058509
nke:Pharmaceuticals
nke:18
nke:2
nke:001431898200001
nke:85218958414
nke:PHARMACEUTICALS-BASE
nke:40006076
Létrehozó:
info:eu-repo/semantics/openAccess