Gastric adenocarcinoma with enteroblastic differentiation : [case report]
  • Metaadatok
Tartalom: http://publicatio.bibl.u-szeged.hu/35480/
Archívum: SZTE Publicatio Repozitórium
Gyűjtemény: Állapot = Nyomdában
Típus = Folyóiratcikk
Cím:
Gastric adenocarcinoma with enteroblastic differentiation : [case report]
Létrehozó:
Ferenczi Ádám
Kuthi Levente
Sejben Anita
Dátum:
2025
Téma:
03.01. Általános orvostudomány
Tartalmi leírás:
Introduction: Gastric adenocarcinoma with enteroblastic differentiation (GAED) is a rare entity with worse prognosis compared to conventional gastric adenocarcinomas. Its histological characteristics are fetal gut-like architecture and tumor cells with cytoplasmic clearing, as well as positive immunohistochemical reaction to at least one of the enteroblastic markers. Hereby, we present a case of GAED with neuroendocrine marker positivity, with whole exome sequencing (WES), and an updated literature review.Case presentation: A 68-year-old woman presented with abdominal pain. Gastric wall thickening raised suspicion of gastric cancer, thus gastroscopy was performed, and biopsy samples were taken, which confirmed malignancy. Neoadjuvant systemic chemotherapy was initiated, and total gastrectomy was performed. Microscopically, pleomorphic polygonal cells were visible with clear cytoplasm and high grade cellular atypia. Alcian blue and PAS stains demonstrated positivity for acidic and neutral mucins. P53 IHC was negative, indicative of null-phenotype, while Syntaxin-1 and Chromogranin showed focal positivity. SALL4 and Glypican 3 were positive, however, AFP displayed only minimal, uncertain positivity. The Ki67 labeling index was 70%. Due to the morphological and immunohistochemical characteristics, the tumor was concluded as GAED with neuroendocrine marker positivity. WES was carried out revealing 4 pathogenic, including TP53, KLHL7, RAPSN, and ACTA1, and 3 likely pathogenic mutations, encompassing PNKP, HNF1A, and ADNP.Discussion: GAED is a rare subtype of gastric adenocarcinomas, representing 0.3-5.4% of all cases and has an unclarified etiology. Our WES results identified new pathogenic and likely pathogenic mutations. From a differential diagnostic point of view, hepatoid adenocarcinoma, and the possibility of metastatic origin has to be excluded.
Nyelv:
angol
Típus:
Folyóiratcikk
PeerReviewed
Formátum:
text
text
Azonosító:
Ferenczi Ádám; Kuthi Levente; Sejben Anita: Gastric adenocarcinoma with enteroblastic differentiation : [case report]. PATHOBIOLOGY, 92. pp. 169-179. ISSN 1015-2008 (2025) (Nyomdában)
doi:10.1159/000543330
Kapcsolat:
35669049
info:eu-repo/semantics/altIdentifier/doi/10.1159/000543330
Létrehozó:
info:eu-repo/semantics/openAccess