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SUMMARY
Given the frequent use of carprofen (CRP) and ketoprofen (KTP) as analgesics in
veterinary practice for relieving pain during surgery, the primary objective of this
trial was to describe the effects of the latter compounds on the hemostatic profile
in dogs after prolonged i.v. administration. All dogs enrolled were subdivided into
two groups of each 5; i.e. involving group I (CRP) and group II (KTP) which received
intravenously the commercially available injectable formulations of CRP and KTP at
the doses of 2.2 mg/kg/day and 3 mg/kg/day bodyweight for 5 days, respectively. In
both groups there were dogs with decreased PT values, which were noted 60 min
after drug administration, showing a continuous decline. Regarding mean APTT values,
there was a continuous decrease in both groups until the 3rd day of the study.
Mean APTT values were decreased, showing significant alterations within time
(p < 0,01), besides there was a significant group-time interaction (p < 0,01). There
were also significant alterations in mean PT values in both groups within time
(p < 0,05), whereas time-group interaction was not significant. The F and D-dimer
concentrations were within reference ranges in both groups, without significant
changes in hemostatic variables throughout the study period. Administration of
CRP or KTP for 5 days caused minor but not important alterations in hemostatic
variables in healthy dogs, which may encourage the use of these drugs for analgesia
during the surgical procedure and for inflammations, when necessary.
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