| Tartalom: |
http://hdl.handle.net/10832/2841 |
| Archívum: |
HUVETA |
| Gyűjtemény: |
Magyar Állatorvosok Lapja
2016
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| Cím: |
A bélnyálkahártya szerepe a xenobiotikumok metabolizmusában, különös tekintettel a citokróm P450 enzimrendszerre - Irodalmi áttekintés
The role of intestinal mucosa in the metabolism of xenobiotics with particular regard to the cytochrome P450 enzyme system - Literature review
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| Létrehozó: |
Kulcsár, Anna
Mátis, Gábor
Kulcsárné Petrilla, Janka
Neogrády, Zsuzsanna
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| Kiadó: |
Magyar Állatorvosok Lapja
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| Dátum: |
2021-03-30T08:02:47Z
2021-03-30T08:02:47Z
2016-04
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| Tartalmi leírás: |
SUMMARY
The aim of the present review is to summarize the recent knowledge about
the role of intestinal mucosa in the biotransformation of xenobiotics. Liver is
the most important organ of biotransformation; however, the small intestinal
mucosa could have an important role in the bioavailability of xenobiotics, as well.
As most of the xenobiotics are absorbed from the small intestine, it could have
a function as a primary barrier, determining the proportion and form of derivates transported from the gut into the portal circulation, thus it could facilitate
the biotransformation function of the liver. Several factors can have impact on
the efficiency of intestinal mucosal biotransformation. Cytochrome P450 (CYP)
enzymes play central role in the metabolism of molecules in the intestinal epithelial cells; the expression and activity of them can be highly influenced by the
interaction with dietary factors or other xenobiotics. Therefore, their significance
in the bioavailability of certain drugs and feed additives cannot be neglected.
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| Nyelv: |
magyar
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| Típus: |
Article
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| Azonosító: |
Magyar Állatorvosok Lapja 138(4), 243-250. (2016)
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