Stability study of nasal powder formulation containing nanosized lamotrigine
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Tartalom: https://www.aph-hsps.hu/acta/index.php/aph/article/view/23
Archívum: Acta Pharmaceutica
Gyűjtemény: Original Research Articles
Cím:
Stability study of nasal powder formulation containing nanosized lamotrigine
Létrehozó:
Gieszinger, Péter
Katona, Gábor
Szabó-Révész, Piroska
Ambrus, Rita
Kiadó:
Hungarian Society for Pharmaceutical Sciences
Dátum:
2020-06-10
Téma:
nasal delivery
stability test
nanotechnology
nasal powder
lamotrigine
formulation
Tartalmi leírás:
Drug administration through the nose offers great possibilities which have been discovered in the past few decades. Besides the most known local effect, systemic and central nervous system effect is also available, the administration is non-painful and the degradation effect of the gastrointestinal tract can be avoided. Amongst the nasal formulations, powders have become more popular as their stability is favorable compared to the liquid formulations and a higher dose can be administered in powder form. The quality insurance and stability of the products in the pharmaceutical field have gained considerable attention in the last decades. Due to this fact, the aim was to execute a long-term stability study of a previously developed, nanosized lamotrigine (LAM) containing nasal powder (NP) formulation. The results of the stability test showed that the NP formulation preserved its key properties (particle size, morphology, structure and in vitro drug release) after 6 months of storage.
Nyelv:
angol
Típus:
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Formátum:
application/pdf
Azonosító:
Forrás:
Acta Pharmaceutica Hungarica; Vol. 90 No. 1 (2020); 27-31
1587-1495
0001-6659
Kapcsolat:
Létrehozó:
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