Model-based Angiogenic Inhibition of Tumor Growth using Adaptive Fuzzy Techniques

Szeles, Annamária; Budapest University of Technology and Economics, Department of Control Engineering and Information Technology

Drexler, Dániel András; Budapest University of Technology and Economics, Department of Control Engineering and Information Technology

Sápi, Johanna; Óbuda University, John von Neumann Faculty of Informatics

Harmati, István; Budapest University of Technology and Economics, Department of Control Engineering and Information Technology

Kovács, Levente; Óbuda University, John von Neumann Faculty of Informatics

L. Kovács is supported by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences

A. Szeles is supported in the frames of TÁMOP 4.2.4. A/1-11-1-2012- 0001

Budapest University of Technology and Economics (BME)

2014-04-07

biomedical systems, tumor treatment, soft computing, fuzzy systems, adaptive control

Fighting tumors is one of the most important problems of medical research. In this paper, antiangiogenic cancer therapy is investigated through its mathematical model.This tumor treatment method targets the endothelium of a growing tumor and belongs to the targeted molecular therapies.The aim of the therapy is not to eliminate the entire tumor,but to decrease the tumor to a minimal volume. An advantage of applying antiangiogenic treatment is that tumor cells show lower tendency of becoming resistant to the applied drugs.Adaptive fuzzy control is implemented for a simplified model to elaborate a control technique which is able to handle the effects of parameter perturbations and uncertainties while keeping the daily and total inhibitor inlet under a given limit.

angol

info:eu-repo/semantics/article

info:eu-repo/semantics/publishedVersion

application/pdf

https://pp.bme.hu/eecs/article/view/7030

10.3311/PPee.7030

Periodica Polytechnica Electrical Engineering and Computer Science; Vol. 58, No. 1 (2014); 29-36

https://pp.bme.hu/eecs/article/view/7030/6339

Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access). As soon as the paper is accepted, finally submitted and edited, the npaper will appear in the "OnlineFirst" page of the journal, thus from this point no other internet-based publication is necessary.