| Tartalmi leírás: |
Cardiomyopathy is frequently diagnosed in the veterinary practice. In the formation of
this abnormality ion channels, among others voltage gated potassium channels (Kv-s)
play a crucial role, since this is the fastest answer to environmental effects on the heart.
Hypothesis: We assumed that the density of the potassium currents is determined by the
amount and distribution of ion channels and modulated by SAP97 and nuclear factors
(i.e.HMGB1). We also hypothesized that the modulation by cytoplasmic HMGB1 is
related to inflammation and this effect may be simulated with ophiobolins. This nuclear
factor is released by necrotic cells but the role in the injury of the heart remains unclear.
Ophiobolin A (OA) is a member of the ophiobolin complex of secondary fungal
metabolites, and it possesses antitumor, antibacterial, antifungal activities. We found
that this ophiobolin agent has the same biological activity on the heart cells as the
HMGB1 published in earlier reports (Szűts et al, 2012; Liu et al. 2010; Yang et al. 2005).
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